Dependence of Porcine Arterial Endothelial Permeability on Wall Shear Stress and Its Related Indices
نویسندگان
چکیده
INTRODUCTION The onset of atherosclerosis may be related to changes in vascular endothelial permeability to macromolecules, which may in turn be induced by wall shear stress or its related indices. We report here an initial experiment that correlates, site-by-site, the albumin uptake in a porcine aortic trifurcation with several measures of wall shear obtained by computational fluid dynamic (CFD) simulation in the same artery segment. The results suggest that the permeability of the vessel decreases monotonically with increasing time-averaged shear stress, while its relationship to other shear related indices is weak or absent.
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